Weight Loss Quick Tips ? 4 Health and Fitness Tips We Should All ...

When it boils down to it we all need to adopt healthy habits. Obesity is a serious problem. Especially in the Westernized world. More and more people are being declared obese by their doctors. Of course this opens the door for the big pharmaceutical companies to come up with new pills, powders and shakes that will supposedly help you shed a million pounds overnight. None of these magic pills and potions work. It?s time we all start taking responsibility for ourselves and take our health more seriously. Far too many people are dying due to obesity related diseases. It has to stop. Here are 4 very simple health and fitness tips we should all start living by.
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Tags: Fitness, Health, Live, Loss, quick, Should, Tips, Weight

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Source: http://www.blogparadise.net/losing-weight/weight-loss-quick-tips-4-health-and-fitness-tips-we-should-all-live-by/

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Erin Andrews joins Fox Sports

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Source: http://news.yahoo.com/erin-andrews-joins-fox-sports-024203902.html

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Researchers block pathway to cancer cell replication

ScienceDaily (July 2, 2012) ? Research suggests that patients with leukemia sometimes relapse because standard chemotherapy fails to kill the self-renewing leukemia initiating cells, often referred to as cancer stem cells. In such cancers, the cells lie dormant for a time, only to later begin cloning, resulting in a return and metastasis of the disease.

One such type of cancer is called pediatric T cell acute lymphoblastic leukemia, or T-ALL, often found in children, who have few treatment options beyond chemotherapy.

A team of researchers -- led by Catriona H. M. Jamieson, MD, PhD, associate professor of medicine at the University of California, San Diego School of Medicine and Director of Stem Cell Research at UC San Diego Moores Cancer Center -- studied these cells in mouse models that had been transplanted with human leukemia cells. They discovered that the leukemia initiating cells which clone, or replicate, themselves most robustly activate the NOTCH1 pathway, usually in the context of a mutation.

Earlier studies showed that as many as half of patients with T-ALL have mutations in the NOTCH1 pathway -- an evolutionarily conserved developmental pathway used during differentiation of many cell and tissue types. The new study shows that when NOTCH1 activation was inhibited in animal models using a monoclonal antibody, the leukemia initiating cells did not survive. In addition, the antibody treatment significantly reduced a subset of these cancer stem cells (identified by the presence of specific markers, CD2 and CD7, on the cell surface.)

"We were able to substantially reduce the potential of these cancer stem cells to self-renew," said Jamieson. "So we're not just getting rid of cancerous cells: we're getting to the root of their resistance to treatment -- leukemic stem cells that lie dormant."

The study results suggest that such therapy would also be effective in other types of cancer stem cells, such as those that cause breast cancer, that also rely on NOTCH1 for self-renewal.

"Therapies based on monoclonal antibodies that inhibit NOTCH 1 are much more selective than using gamma-secretase inhibitors, which also block other essential cellular functions in addition to the NOTCH1 signaling pathway," said contributor A. Thomas Look, MD of Dana-Farber/Children Hospital Cancer Center in Boston. "We are excited about the promise of NOTCH1-specific antibodies to counter resistance to therapy in T-ALL and possibly additional types of cancer."

In investigating the role of NOTCH1 activation in cancer cell cloning, the researchers showed that leukemia initiating cells possess enhanced survival and self-renewal potential in specific blood-cell, or hematopoietic, niches: the microenvironment of the body in which the cells live and self-renew.

The scientists studied the molecular characterization of CD34+ cells -- a protein that shows expression in early hematopoietic cells and that facilitates cell migration -- from a dozen T-ALL patient samples.

They found that mutations in NOTCH1 and other genes capable of promoting the survival of cancer stem cells co-existed in the CD34+ niche. Mice transplanted with CD34-enriched NOTCH1 mutated T-ALL cells demonstrated significantly greater leukemic cloning potential than did mice without the NOTCH1 mutation. The mutated cells were uniquely susceptible to targeted inhibition with a human monoclonal antibody, according to the scientists.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/r2ufKrbgmxY/120702162325.htm

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Huge demo as Hong Kong marks 15 years under China

Tens of thousands of protestors filled the streets of Hong Kong Sunday, adamant there was nothing to cheer as the former British colony marked 15 years of Chinese rule and swore in a new leader.

The vast rally came after Leung Chun-ying, a millionaire property consultant seen as close to China's communist rulers, took the chief executive's oath in front of Chinese President Hu Jintao -- who had his speech interrupted.

Hu's visit and Leung's inauguration have become focal points for growing discontent towards Beijing, which has surged to a new post-handover high amid soaring housing costs, limited democracy and perceived meddling by China.

"Hong Kong has become much worse off," Eric Lai of the Civil Human Rights Front told the marchers. "Our rights are under serious threat."

The crowd ranged from engineers and civil servants to maids and students, and represented groups from the Falun Gong spiritual movement to trade unions, as well as ordinary citizens young and old.

In sweltering heat it took them nearly three hours to file out of the park where they gathered, organisers said, and they blocked streets far across the city, stranding buses and trams as they surrounded them.

Mostly clad in the mourning colours of black and white, they carried placards calling for "One person one vote" and chanted "Power to the people", sometimes in more of a carnival atmosphere, complete with drums and songs.

The financial centre enjoys significant autonomy and civil liberties unheard of on the mainland under the "one country, two systems" model covering its return to China in 1997 after more than a century of British rule.

But marcher Jacky Lim, 37, who carried Hong Kong's former colonial flag bearing the British union jack, said: "There is nothing worth celebrating today. Hong Kong is being gradually destroyed by the Communist Party.

"The direct interference of Beijing in the election of Leung Chun-ying is a clear example," he said.

Hong Kong does not yet choose its leader by universal suffrage, and Leung was elected as chief executive in March by a special committee stacked with pro-Beijing business elites.

A spokesman for the Hong Kong government said it "fully respected" freedom of expression and the right to "take part in processions", and would listen to the demonstrators' views "in a humble manner".

Organiser estimates of crowd size were not immediately available because it was so large, while police gave a preliminary figure of 55,000, although that was likely to rise.

Earlier, as President Hu began his speech to around 2,300 guests at Leung's inauguration, a protestor inside the harbourfront venue repeatedly shouted "End one-party rule".

The man also referred to the crushing of democracy protests on Tiananmen Square in Beijing on June 4, 1989, and was rapidly bundled away by security personnel, while the audience drowned him out with extended applause for Hu.

Beijing's support for "one country, two systems" and the right of the people of Hong Kong to rule the territory was "unwavering", said Hu.

"We will follow the Basic Law... to continue to advance democratic development in Hong Kong," said the president, who will step down as part of a once-in-a-decade leadership transition in Beijing starting later this year.

Hu -- who said Friday he hoped to "walk more" and understand Hong Kongers' "life and expectations" -- left for Beijing before the march began.

Stifling security was imposed for his three-day visit, with police using pepper spray on demonstrators at one point on Saturday, and briefly detaining a Hong Kong reporter who shouted a question about Tiananmen at Hu.

China's economic rise has helped spur impressive growth in Hong Kong and boost the city's status, and supporters packed a stadium Sunday for a gala featuring a People's Liberation Army parachute display.

But tensions are growing between the seven million locals and their northern neighbours, with newly rich Chinese mainlanders accused of everything from pushing up property prices to monopolising schools and maternity beds.

A poll released by Hong Kong University last week showed mistrust towards Beijing at 37 percent, a post-handover high, and the number of Hong Kongers identifying themselves primarily as citizens of China plunged to a 13-year low in another survey.

Discontent against the local authorities is also widespread amid complaints about a widening gap between rich and poor.

Leung has promised to tackle the grievances but ahead of his swearing-in, a group of demonstrators burned his portrait.

"If we work together, I am sure Hong Kong -- the Pearl of the Orient -- will sparkle again," Leung said in his speech.

Source: http://news.yahoo.com/hong-kong-leader-sworn-015730557.html

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Stocks face questions entering 2nd half of '12

By Angela Moon, Reuters

NEW YORK -- U.S. stocks finished the first half of the year with a bang as investors welcomed news that the euro zone is a step closer to solving its 30-month-long debt crisis. Now for the question: Is this rally strong enough to last for more than a day?

The S&P 500 and the Nasdaq posted their best daily percentage gains since December on Friday after an agreement by European leaders to stabilize the region's troubled banks, a pact that helped remove some of the uncertainty that has plagued markets.

"That is the major question. Can this fuel a longer-term rally? It can, but only to some degree if, over the weekend and the course of next week, we don't see any major push back or headlines that suggest that this deal is not going to happen," said Quincy Krosby, a market strategist at Prudential Financial.

"But I don't think this is a major game changer. I do, however, think that this is really the first time we got a relatively immediate answer to what they (the euro-zone leaders) are going to do about the issue."

Under pressure to prevent a catastrophic breakup of their single currency, euro-zone leaders agreed on Friday to let their rescue fund inject aid directly into stricken banks starting next year and intervene in bond markets to support troubled member-states.

They also pledged to create a single banking supervisor for euro-zone banks based around the European Central Bank in a landmark first step toward a European banking union that could help shore up struggling member Spain.

Wall Street's previous reaction to euro-zone bailout packages or other rescue plans had been somewhat muted. Initial gains would quickly disappear by the day's end as investors realized that there isn't a quick fix to the region's problems.?

On Friday, it was a different story. The three major U.S. stock indexes jumped 1.5 percent to 2 percent shortly after the opening bell on news of the euro-zone agreement.

By the close, stocks ended at session highs with the major indexes up between 2 percent and 3 percent. The Dow Jones industrial average surged 277.83 points, or 2.20 percent, to end at 12,880.09. The Standard & Poor's 500 Index jumped 33.12 points, or 2.49 percent, to finish at 1,362.16. And the Nasdaq Composite Index shot up 85.56 points, or 3.00 percent, to close at 2,935.05.

For the week, the Dow rose 1.9 percent, the S&P 500 advanced 2 percent and the Nasdaq gained 1.5 percent.

For the month, the Dow added 3.9 percent, the S&P 500 rose 4 percent and the Nasdaq climbed 3.8 percent.

But for the second quarter, the Dow dropped 2.5 percent, the S&P 500 slid 3.3 percent and the Nasdaq lost 5.1 percent.

Despite the weak second quarter, the three major U.S. stock indexes wrapped up the first half of the year with decent gains: The Dow was up 5.4 percent, the S&P 500 was up 8.3 percent and the Nasdaq was up 12.7 percent.

"The next question is whether the ESM/EFSF will have enough capital and assuming they don't, will the ECB chip in by giving it a bank license, thus leveraging its size. That is yet to be determined," said Peter Boockvar, an equity strategist at Miller Tabak & Co in New York.

"For now, party on and turn that hourglass over as more time has been bought. But only the symptoms are being fought as the underlying disease of excessive debt and lack of growth still remains."

The leaders of the 17 European Union countries agreed on a series of short-term steps to shore up their monetary union and bring down the borrowing costs of Spain and Italy, seen as too big to bail out.

To that end, the euro zone's temporary European Financial Stability Facility (EFSF) and permanent European Stability Mechanism (ESM) rescue funds will be used "in a flexible and efficient manner in order to stabilize markets" to support countries that comply with EU budget policy recommendations, a joint statement said.

Any market reaction to further developments this week could be exaggerated by lighter-than-usual volume. Wall Street trading desks may be more sparsely populated because it will be a short week. The U.S. stock market will be closed on Wednesday, the Fourth of July, in observance of Independence Day.

The market's focus will shift to the European Central Bank this week as investors wait to see whether it cuts interest rates to complement the measures taken by EU leaders to shore up banks and bring down borrowing costs for Spain and Italy.?

Most economists polled by Reuters expect the ECB to cut borrowing costs on Thursday, July 5, at its meeting, which takes place against a darkening economic backdrop.

But internal resistance to the central bank reviving its bond-buying program remains high. The ECB has already loosened its collateral rules to make it easier for banks in Spain to access its funds.

"Investors have to be cautious because the market may be getting ahead of itself. We really don't have any details. The big question is still what direction the ECB takes" this week, said Omer Esiner, chief market analyst at Commonwealth Foreign Exchange in Washington.

"It's (the EU deal) certainly not a silver bullet for the debt crisis, but the market is kind of acting like it is. It may set us up for another push down in the weeks ahead."

Stocks had enjoyed a run earlier this month on hopes that global central banks would announce additional measures to stimulate economic growth, which has been tepid.

On June 20, the Federal Reserve extended its "Operation Twist" program to sell short-term securities and buy longer-term ones to keep long-term borrowing costs down. But investors were disappointed when U.S. Federal Reserve Chairman Ben Bernanke, who spoke at a news conference after the Fed's two-day policy meeting, gave few hints that further monetary stimulus was imminent, denting hopes of cheap money in the equities market.

European bond yields will be closely watched this week. Madrid will auction three-year, four-year and 10-year bonds at a primary auction on Thursday in another big test for Spanish yields that are still not far below 7 percent.

France will sell between 7 billion and 8 billion euros in long-term bonds on Thursday.

This week's data includes the Institute for Supply Management's U.S. manufacturing index and construction spending on Monday, followed by factory orders and June car sales on Tuesday.

After Wednesday's holiday, investors will face a blitz of economic indicators. On Thursday, weekly jobless claims and mortgage data, ADP's private-sector payrolls report and the ISM's U.S. services-sector index will be released.

On Friday, the government's June nonfarm payrolls report will come out. Economists polled by Reuters have forecast a gain of 90,000 jobs, with the U.S. unemployment rate holding steady at 8.2 percent.?

Below, CNBC's Tyler Mathisen looks ahead to what are likely to be next week's top business and financial stories.

Copyright 2011 Thomson Reuters. Click for restrictions.

Source: http://bottomline.msnbc.msn.com/_news/2012/07/01/12508970-2nd-half-of-year-shapes-up-as-big-question-for-stocks?lite

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Woman, 49, Starts Uncaged Cuba-Florida 103-Mile Swim

British-Australian swimmer Penny Palfrey and her husband, Chris, rub lubricating cream on her body Friday in preparation for her bid to complete a record swim from Cuba to Florida. (RAMON ESPINOSA | THE ASSOCIATED PRESS)

Published: Friday, June 29, 2012 at 9:06 p.m.

Last Modified: Friday, June 29, 2012 at 9:06 p.m.

HAVANA | Marathon swimmer Penny Palfrey set out on a record bid to traverse the Straits of Florida early Friday, a 103-mile unassisted swim testing the limits of human endurance and the will of the high seas.

Slathered with sunblock and lubricant to prevent chafing, the British-born Australian bade farewell to onlookers, dove headfirst into the calm, bathwater-warm seas off Havana and began stroking slowly northward with a kayaker as escort.

"There's a lot of work that's gone into this over the past year," Palfrey said, thanking her husband, her team and Cuban officials who helped facilitate the trip. "It's all coming together, and so exciting to finally get to this point where we can get started."

After her departure, a member of Palfrey's crew was keeping fans up to date via social media.

"Swimming strong. Great conditions. Some jellies, but not bad," read one tweet. By late morning she had covered 7.5 nautical miles, or 8.6 miles, as Cuba disappeared from sight.

Palfrey will have to fight through physical and mental fatigue while fending off dehydration, hypothermia and dangerous marine life. She estimates that it will take 40 to 50 hours to make the crossing, and the currents will determine where in Florida she comes onshore.

If Palfrey succeeds, she'll go in the record books as the first woman to swim the Straits without the aid of a shark cage. Instead she's relying on equipment that surrounds her with an electrical field to deter the predators.

Australian Susie Maroney made the crossing in 1997 at age 22, but with a shark cage. American Diana Nyad made two unsuccessful cageless attempts last year on either side of her 62nd birthday, but had to call them off because of a debilitating asthma attack and painful Portuguese man o' war stings. She plans to try again this summer.

Palfrey, a 49-year-old mother and grandmother, is more than a decade younger than Nyad.

She was wearing a regular sporting swimsuit instead of a wetsuit, and planned to put on a porous, non-buoyant Lycra bodysuit that provides cover down to the wrists and ankles whenever jellyfish may be a threat.

That's particularly the case at night, according to her support team of more than a dozen navigators, handlers and medical personnel who were escorting her on the 44-foot catamaran Sealuver.

Palfrey is no stranger to jellyfish stings, which forced her to abort two past swims in Hawaii.

A 20-year veteran of distance swimming, her personal best came last year when she completed 67 miles between Little Cayman and Grand Cayman islands.

At a news conference Thursday, Palfrey said she swam competitively in her youth but only discovered ultra-long-distance swimming later in life.

"I spent my teenage years swimming and studying, and then I've spent a lot of time raising my family and supporting my husband's business," she said. "And now I feel that it's my window in life to do something that I love to do. I don't believe that I can do it much later in life so this is my opportunity now. "

Friday morning she was upbeat and focused on the task at hand as she prepared to set off from the Hemingway Marina in western Havana.

Asked about the first thing she planned to do on arrival in Florida, she laughed and said, "get out of the water."

Source: http://www.theledger.com/article/20120629/news/120629224

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